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News: FDA Approves New CRC Drug for Phase I Clinical Trial

Posted on July 31, 2014

Exciting news in the colon cancer world! Last week, the experimental drug MGD007 was cleared by the FDA for Phase I clinical trials in colon cancer, scheduled to start later this year. MGD007 is different from other drugs currently available because it kills cancer cells in a different way. Specifically, it binds to a protein on immune system cells (or T-cells) and directs them to kill cells that express a protein found on 95% of primary and metastatic colon cancer cells.

This means MGD007 has the potential to be highly effective in shrinking colon and rectal tumors in much more targeted way and with a lower dosage, so it’s less toxic. Until this point, the drug has been effective on cell lines and in animals; we’re thrilled to see the results on this upcoming Phase I human clinical trial. This data was presented to thousands of medical professionals, researchers and advocates at the 2014 American Association of Cancer Research (AACR) meeting. For more details, take a look at the full release.

Interested in learning more about clinical trials and how you can participate? Check out our Clinical Trials Matching Service.

Don’t forget, the Colon Cancer Alliance serves as a source of information about colon health. If you have questions or are in need of support, please contact our free Helpline at (877) 422-2030. We’re here to help.

4 Responses to “News: FDA Approves New CRC Drug for Phase I Clinical Trial”

  1. Cleo Mobley says:

    Thank you, my son died from colon cancer this year and he might still be here if this had been available. I miss my soon a lot and am so pleased that some one else may not lose theirs. God Bless!

  2. Roberta Clark says:

    I am a Stage IV colon cancer patient. I was dx in 2009. I am currently on Stivarga which I started in January of this year. So far my tumors have remained stable. I have tumors in my lungs and liver. My next scan is scheduled for August 4th. I have been told that Stivarga is my last hope. If this med doesn’t work my only options to continue to fight my colon cancer is to go into clinical trials. I would like more information on this promising new drug in case I may need to see if I qualify as a candidate. Thank you for your assistance.

    • Becky Kerner says:

      Hi Roberta – thanks so much for reaching out and sharing. I would urge you to call our Clinical Trial Matching Service and chat with one of our patient navigators about options that may work for you. The number is 866-278-0392 and they’re available Monday through Friday, 8:30am–6:30pm ET. You can also check out more information on the website at You are also always welcome to call our Colon Cancer Alliance free Helpline if you’d like to chat with someone from our patient support team about anything colon cancer related, including general clinical trial information. That number is (877) 422-2030. Don’t hesitate to reach out to us!

  3. mareena Hurtado says:

    Note.I am my Husbands caregiver. would like information on this new drug. he is currently on stivarga now going on cycle number 5 although he has many symptoms my fear is for how long. any information would be appreciated and thank you.

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